PUBLICATIONS

2020| 2019| 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010

2020

  1. Masking Phosphate with Rare-Earth Elements Enables Selective Detection of Arsenate by Dipycolylamine-Zn(II) Chemosensor,Nutsara Mekjinda, Supho Phunnarungsi, Vithaya Ruangpornvisuti, Raymond J. Ritchie,Itaru Hamachi, Akio Ojida, Jirarut Wongkongkatep,
    Scientific Reports
    , volume 10, 2656 (2020) .
  2. Fluorescence detection of metabolic activity of the fatty acid beta oxidation pathway in living cells,Shohei Uchinomiya, Naoya Matsunaga, Koichiro Kamoda, Ryosuke Kawagoe, Akito Tsuruta, Shigehiro Ohdo, Akio Ojida,
    Chem Commun
    , 56, 3023-3026 (2020) .
  3. Fluorescence Differentiation of ATP-Related Multiple Enzymatic Activities in Synovial Fluid as a Marker of Calcium Pyrophosphate Deposition Disease Using Kyoto Green,Nattha Yongwattana , Nutsara Mekjinda, Tulyapruek Tawonsawatruk, Itaru Hamachi, Akio Ojida, JirarutWongkongkatep,
    Molecules
    , 25, 1116 (2020) .
  4. In vivo targeting endogenous proteins with reactive small molecules, Naoya Shindo, Akio Ojida, Handbook of In Vivo Chemistry in Mice. From Lab to Living System,Tanaka, K., Vong, K. Eds.
    Wiley-VCH,
    ; 281-307 (2020) .
  5. Selective Covalent Targeting of Mutated EGFR(T790M) with Chlorofluoroacetamide-Pyrimidines, Mami Sato, Hirokazu Fuchida, Naoya Shindo, Keiko Kuwata, Keisuke Tokunaga, Guo Xiao-Lin, Ryo Inamori, Keitaro Hosokawa, Kosuke Watari, Tomohiro Shibata, Naoya Matsunaga, Satoru Koyanagi, Shigehiro Ohdo, Mayumi Ono, Akio Ojida,
    ACS Medicinal Chemistry Letters,
    11,1137-1144 (2020) .
  6. Fluorescence Detection of Deoxyadenosine in Cordyceps spp. by Indicator Displacement Assay, Arinta Agnie Dewantari, Nattha Yongwattana, Panwajee Payongsri, Sawinee Seemakhan, Suparerk Borwornpinyo, Akio Ojida, Jirarut Wongkongkatep,
    Molecules,
    25, 2045 (2020) .
  7. Fluorescence Determination of Soluble Pyrophosphate Levels in Synovial Fluid as a Marker of Pseudogout Using Middle Point of Quantification Concept and Molecular Sensor, Nattha Yongwattana, Nutsara Mekjinda, Wannee Thepsing, Supasara Ounsuk, Pravit Wongkongkatep, Tulyapruek Tawonsawatruk, Itaru Hamachi, Akio Ojida, Jirarut Wongkongkatep,
    ScienceAsia,
    46S, 36-42 (2020) .
  8. Trimethyl-Substituted Carbamate as a Versatile Self-Immolative Linker for Fluorescence Detection of Enzyme Reactions, Noriaki Nakamura, Shohei Uchinomiya, Kazuya Inoue, Akio Ojida,
    Molecules,
    25, 2153 (2020) .
  9. Affinity for the Interface Underpins Potency of Antibodies Operating in Membrane Environments, Edurne Rujas, Sara Insausti, Daniel P. Leaman, Pablo Carravilla, Saul Gonza´ lez-Resines, Vale´ rie Monceaux, Rube´n Sa´ nchez-Eugenia, Miguel Garcı´a-Porras, Ibon Iloro, Lei Zhang, Fe´ lix Elortza, Jean-Philippe Julien, Asier Sae´ z-Cirio´ n, Michael B. Zwick, Christian Eggeling, Akio Ojida, Carmen Domene, Jose M.M. Caaveiro, Jose´ L. Nieva,
    Cell Reports,
    32, 108037 (2020) .
  10. Fragment-Based Discovery of Irreversible Covalent Inhibitors of Cysteine Proteases Using Chlorofluoroacetamide Library, Chizuru Miura, Naoya Shindo, Kei Okamoto, Tomoyo Osawa, Akio Ojida,
    Chem. Pharm. Bull,
    68, 11, 1074-1081 (2020) .
  11. Bicyclobutane Carboxylic Amide as a Cysteine-Directed Strained Electrophile for Selective Targeting of Proteins, Keisuke Tokunaga, Mami Sato, Keiko Kuwata, Chizuru Miura, Hirokazu Fuchida, Naoya Matsunaga, Satoru Koyanagi, Shigehiro Ohdo, Naoya Shindo, and Akio Ojida,
    J. Am. Chem. Soc, 
    142,43,18522-18531(2020).         .

2019

  1. Selective and reversible modification of kinase cysteines with chlorofluoroacetamides, Naoya Shindo, Hirokazu Fuchida, Mami Sato, Kosuke Watari, Tomohiro Shibata, Keiko Kuwata, Chizuru Miura, Kei Okamoto, Yuji Hatsuyama, Keisuke Tokunaga, Seiichi Sakamoto, Satoshi Morimoto, Yoshito Abe, Mitsunori Shiroishi, Jose M. M. Caaveiro, Tadashi Ueda, Tomonori Tamura, Naoya Matsunaga, Takaharu Nakao, Satoru Koyanagi, Shigehiro Ohdo, Yasuchika Yamaguchi, Itaru Hamachi, Mayumi Ono, Akio Ojida,
    Nature Chemical Biology
    , volume 15, 250–258 (2019) .
  2. Optimized Reaction Pair of the CysHis Tag and Ni(II)-NTA Probe for Highly Selective Chemical Labeling of Membrane Proteins, N. Zenmyo, H. Tokumaru, S. Uchinomiya, H. Fuchida, S. Tabata, I. Hamachi, R. Shigemoto, A. Ojida,
    Bull. Chem. Soc. Jpn.
    , 92, 995-1000 (2019).
  3. コバレントドラッグ創薬のための創薬有機化学、進藤 直哉、王子田 彰夫、
    ファルマシア, 55, Vol.10, 939-943 (2019).
  4. 生体夾雑環境での創薬有機化学の新展開、王子田 彰夫、
    化学と工業, 72, vol.5, 407-409 (2019).
  5. 蛍光小分子プローブによる代謝経路活性の生細胞イメージング、内之宮 祥平、王子田 彰夫、
    化学工業, 70, Vol.5, 248-254 (2019).
  6. タンパク質を標的とした創薬有機化学の新展開、佐藤 磨美、王子田 彰夫、
    現代化学, 577,Vol.4, 32-36 (2019).
  7. Electron Microscopic Detection of Single Membrane Proteins by a Specific Chemical Labeling, Shigekazu Tabata, Marijo Jevtic, Nobutaka Kurashige, Hirokazu Fuchida, Munetsugu Kido, Kazushi Tani, Naoki Zenmyo, Shohei Uchinomiya, Harumi Harada, Makoto Itakura, Itaru Hamachi, Ryuichi Shigemoto, Akio Ojida,
    iScience, 22, 256-268 (2019).

2018

  1. Hypoxia-induced interaction of filamin with Drp1 causes mitochondrial hyperfission–associated myocardial senescence, A. Nishimura, T. Shimauchi, T. Tanaka, K. Shimoda, T. Toyama, N. Kitajima, T. Ishikawa, N. Shindo, T. Numaga-Tomita, S. Yasuda, Y. Sato, K. Kuwahara, Y. Kumagai, T. Akaike, T. Ide, A. Ojida, Y. Mori, M. Nishida,
    Science Signaling, 11, eaat5185 (2018).
  2. Internal‐Edge‐Substituted Coumarin‐Fused [6]Helicenes: Asymmetric Synthesis, Structural Features, and Control of Self‐Assembly, K. Usui, K. Yamamoto, Y. Ueno, K. Igawa, R. Hagihara, T. Masuda, A. Ojida, S. Karasawa, K. Tomooka, G. Hirai, H. Suemune,
    Chem. Euro. J., 24, 14617-14621 (2018).

2017

  1. Reversible Ratiometric Detection of Highly Reactive Hydropersulfides Using a FRET-Based Dual Emission Fluorescent Probe, R. Kawagoe, I. Takashima, S. Uchinomiya, A. Ojida, 
    Chemical Science, 8, 1134-1140 (2017).
  2. Fluorescence Sensing of Inorganic Phosphate and Pyrophosphate Using Small Molecular Sensors and Their Applications, J. Wongkongkatep, A. Ojida. I. Hamachi, 
    Topics in Current Chemistry, 375:30 (2017).
  3. Discovery of highly reactive peptide tag by ELISA-type screening for specific cysteine conjugation, N. Kurashige, H. Fuchida, S. Tabata, S. Uchinomiya, A. Ojida,
  4. Bioorganic & Medicinal Chemistry Letters, 27, 3486-3489 (2017).
  5. A host–guest system based on collagen-like triple-helix hybridization, N. Delsuc*, S. Uchinomiya, A. Ojida, I. Hamachi
  6. Chemical Communications, 53, 6856-6859 (2017).
  7. コバレント阻害剤の標的特異性向上を目指した新規反応基の探索とEGFR阻害剤への応用、進藤 直哉、王子田 彰夫 
    MEDCHEM NEWS, 27, 92-99 (2017).

2016

  1. 新しい蛍光センシング機構開発に基づいた細胞機能解析、王子田 彰夫、高嶋 一平 
    薬学雑誌, 136, 3-7 (2016).
  2. Cell Surface-Anchored Fluorescent Probe Capable of Real-Time Imaging of Single Mast Cell Degranulation Based on Histamine-Induced Coordination Displacement, Y. Oshikawa, K. Furuta, S. Tanaka, A. Ojida, 
    Analytical Chemistry, 88, 1526-1529 (2016).
  3. Intracellular delivery of chemical probes using a glutathione-responsive traceless tag_, Eriko Aoyama, Hirokazu Fuchida, Yuji Oshikawa, Shohei Uchinomiya, Akio Ojida,  
    Chemical Communications, 52, 7715-7718 (2016).
  4. Inhibition of G0/G1 switch 2 ameliorates renal inflammation in chronic kidney disease, N. Matsuanga, N. Shindo (5/26), A. Ojida (24 /26), S. Koyanagi, S. Ohdo,(他21名), 
    EBioMedicin, 13, 262–273 (2016).

2015

  1. Rapid and Quantitative Fluorescence Detection of Pathogenic Spore-forming Bacteria Using a Xanthene-Zn(II) Complex Chemosensor, P. Tiposoth, S. Khamsakhon, N. Ketsub, T. Pongtharangkul, I. Takashima, A. Ojida, I. Hamachi, J. Wongkongkatep,
    Sensor and Actuators B: Chemical., 209, 606-612 (2015). 
  2. Development of an AND Logic-Gate-Type Fluorescent Probe for Ratiometric Imaging of Autolysosome in Cell Autophagy_,  
    I. Takashima, R. Kawagoe, I. Hamachi, A. Ojida,
    Chem. Eur. J. 21, 2038-2044 (2015).
  3. Design of Coordination Interaction of Zn(II) Complex with Oligo-Aspartate Peptide to Afford a High-Affinity Tag­Probe Pair, H. Fuchida, S. Tabata, N. Shindo, I. Takashima, Q. Leng, Y. Hatsuyama, I. Hamachi, A. Ojida,  
    Bull. Chem. Soc. Jpn. 88, 784-791 (2015).
  4. Rational Design of a Ratiometric Fluorescent Probe Based on Arene–Metal-Ion Contact for Endogenous Hydrogen Sulfide Detection in Living Cells_, R. Kawagoe, I. Takashima, K. Usui, A. Kanegae, Y. Ozawa, A. Ojida,  
    ChemBioChem 16, 1608-1615 (2015).
  5. Quantification of Amino Groups on Solid Surfaces Using Cleavable Fluorescent Compounds, S. Shiota, S. Yamamoto, A. Shimomura, A. Ojida, T. Nishino,T. Maruyama, 
    Langmuir 31, 8824-8829 (2015).
  6. Design and synthesis of a novel pre-column derivatization reagent with a 6-methoxy-4-quinolone moiety for fluorescence and tandem mass spectrometric detection and its application to chiral amino acid analysis,Tsubasa Oyama, Eiichi Negishi, Hirohisa Onigahara, Nao Kusano, Yurika Miyoshi, Masashi Mita, Manabu Nakazono, Sumio Ohtsuki, Akio Ojida, Wolfgang Lindner, Kenji Hamase,
    Journal of Pharmaceutical and Biomedical Analysis, 116, 71-79 (2015)

2014

  1. Peptide Tag/Probe Pairs Based on the Coordination Chemistry for Protein Labeling, S. Uchinomiya, A. Ojida, I. Hamachi*
    Inorg. Chem., 53, 1816-1823 (2014).
  2. Coordination Ligand Exchange of a Xanthene Probe–Ce(III) Complex for Selective Fluorescence Sensing of Inorganic Pyrophosphate, E. Kittiloipaisan, I. Takashima, W. Kiatpathomchai, J. Wongkongkatep*, A. Ojida*
    Chem. Commun., 50, 2126-2128 (2014).
  3. Design of Ratiometric Fluorescent Probes Based on Arene–Metal-Ion Interactions and Their Application to CdII and Hydrogen Sulfide Imaging in Living Cells, I. Takashima, M. Kinoshita, R. Kawagoe, S. Nakagawa, M. Sugimoto, I. Hamachi, A. Ojida*
    Chemistry-an European Journal, 20, 2184-2192 (2014).
  4. Design of a Binuclear Ni(II)-Iminodiacetic Acid (IDA) Complex for Selective Recognition and Covalent Labeling of His-tag Fused Proteins , T. Ikuko, H. Fuchida, S. Tabata, N. Shindo, S. Uchinomiya, I. Hamachi,A. Ojida*
    Bioorg. Med. Chem. Lett. , 24, 2855-2858 (2014).
  5. Aza-Crown-Ether-Appended Xanthene: Selective Ratiometric Fluorescent Probe for Silver(I) Ion Based on AreneMetal Ion 
    Interaction, I. Takashima,  A. Kanegae, M. Sugimoto, A. Ojida* 
    Inorg. Chem.,  53, 7080-7082(2014).

2013

  1. PET-dependent Fluorescence Sensing of Enzyme Reactions Using the Large and Tunable pKa Shift of Aliphatic Amines, Yuji Oshikawa, A. Ojida*
    Chem. Commun., 49, 11373-11375 (2013).
  2. Protein Organic Chemistry and Applications for Labeling and Engineering in Live-Cell Systems, Y. Takaoka, A. Ojida, I, Hamachi*
    Angew. Chem. Int. Ed., 52, 4088-4106 (2013).
  3. タンパク質機能化のためのケミカルバイオロジー研究、田畑 栄一、王子田 彰夫
    表面, 51, 26-38 (2013).
  4. In-Cell Covalent Labeling of Retactive His-tag Fused Proteins, S. Uchinomiya, H. Nonaka, S. Wakayama, A. Ojida, I. Hamachi*
    Chem. Commun., 49, 5022-5024 (2013).

2012

  1. Organelle-Localizable Fluorescent Chemosensors for Site-Specific Multicolor Imaging of Nucleoside Polyphosphate Dynamics in Living Cells, Y. Kurishita, K. Kohira, A. Ojida *, I. Hamachi*
    J. Am. Chem. Soc., 134,18779-18789 (2012).
  2. Ligand-Directed Acyl Imidazole Chemistry for Labeling of Membrane-Bound Proteins on Live Cells, S. Fujishima, R. Yasui, T. Miki, A. Ojida*, I. Hamachi*
    J. Am. Chem. Soc., 134, 3961-3964 (2012).
  3. Design of a multinuclear Zn(II) complex as a new molecular probe for fluorescence imaging of His-tag fused proteins, S. Fujishima, H. Nonaka, S. Uchinomiya, Y. A. Kawase, A. Ojida*, I. Hamachi*
    Chem. Commun., 48, 594-596 (2012).
  4. Label-Free Fluorescent Detection of Loop-Mediated Isothermal Amplification of Nucleic Acid Using Pyrophosphate-Selective Xanthene-based Zn(II)-Coordination Chemosensor, E. Kittiloipaisan, A. Ojida, I. Hamachi, Y. Seerang-Nun, W. Kiatpathomchai, J.Wongkongkatep*
    Chem. Lett., 41, 1666-1668 (2012).

2011

  1. Rigid Luminescent Bis-Zinc(II)-Bis-Cyclen Complexes for the Detection of Phosphate Anions and Non-Covalent Protein Labeling in Aqueous Solution, M. Bhuyan, E. Katatev, S. Stadlbauer, H. Nonaka, A. Ojida, I. Hamachi, B. Konig*
    Eur. J. Org. Chem., 15, 2807-2817 (2011).
  2. 小分子プローブによるタンパク質ラベル化法、王子田 彰夫
    ぶんせき, 275-281 (2011).
  3. Discovery of orteronel (TAK-700), a naphthylmethylimidazole derivative, as a highly selective 17,20-lyase inhibitor with potential utility in the treatment of prostate cancer, T. Kaku, T. Hitaka, A. OJIDA, N. Matsunaga, M. Adachi, T. Tanaka, T. Hara, M. Yamaoka, M. Kusaka, T. Okuda, S. Asahi, S. Furuya, A. Tasaka*
    Bioorganic Medicinal Chemistry, 19, 6383-6399 (2011)
  4. 17,20-Lyase inhibitors. Part 4: Design, synthesis and structure–activity relationships of naphthylmethylimidazole derivatives as novel 17,20-lyase inhibitors, T. Kaku, N. Matsunaga, A. Ojida, T. Tanaka, T. Hara, M. Yamaoka, M. Kusaka, A. Tasaka*
    Bioorganic Medicinal Chemistry, 19, 1751-1770 (2011)

2010

  1. Selective Covalent Labeling of Tag-Fused GPCR Proteins on Live Cell Surface with a Synthetic Probe for Their Functional Analysis, H. Nonaka, S. Fujishima, S. Uchinomiya, A. Ojida*, I. Hamachi*
    J. Am. Chem. Soc., 132, 9301-9309 (2010).
  2. Rational Design of FRET-Based Ratiometric Chemosensors for in Vitro and in Cell Fluorescence Analyses of Nucleoside Polyphosphates, Y. Kurishita, T. Kohira, A. Ojida*, I. Hamachi*
    J. Am. Chem. Soc., 132, 13290-13299 (2010).
  3. Development of Highly Sensitive Fluorescent Probes for Detection of Intracellular Copper(I) in Living Systems, M. Taki*, S. Itoshi, A. Ojida, I. Hamachi, Y. Yamamoto*
    J. Am. Chem. Soc., 132, 5938-5939 (2010).
  4. Binuclear NiII-DpaTyr Complex as a High Affinity Probe for an Oligo-Aspartate Tag Tethered to Proteins, A. Ojida, S. Fujishma, K. Honda, H. Nonaka, S. Uchinomiya, I. Hamachi*
    Chemistry Asian Journal, 5, 877-886 (2010).
  5. Thermoresponsive Fluorescent Sensor Based on Core/Shell Nanocomposite Composed of Gold Nanoparticles and Poly(N-isopropylacrylamide), J. Wongkongkatep, R. Ladadat, W. Lappermpunsap, P. Wongkongkatep, P. Phinyocheep, A. Ojida, I. Hamachi*
    Chem. Lett., 39, 184-185 (2010).
  6. タンパク質機能解析のための特異的タンパク質ラベル化法、王子田 彰夫、浜地 格
    生命現象を理解する分子ツール(化学同人), 47-53 (2010).
  7. 小分子プローブを用いたタンパク質ラベル化法の新展開、王子田 彰夫、野中 洋、浜地 格
    バイオサイエンスとインダストリー, 68, 194-197 (2010).